This research investigates whether access to jobs affects poor households’ residential location choices using data from individual households in the Chicago Metropolitan Area. Our results, based on discrete choice models, show that the effects of job accessibility on household location choices are contingent upon households’ automobile ownership and employment status. Places with higher job accessibility by public transit mode are more likely to attract poor households that do not own cars but have at least one employed worker or one labour force participant, while job accessibility by automobile travel mode has no positive effect on the location choices of poor households who own automobiles. The results stress the importance of job accessibility for those poor households with limited transportation mobility but strong needs for access to jobs.